<i>APOE</i> Genotype Modulates the Relationship of Stroke With Dementia Risk: Associations and Peripheral Clues for Biological Mechanisms

Stroke interacts with <i>APOE</i> ε4 to influence dementia, with the association being more pronounced in <i>APOE</i> ε4 non-carriers. Future studies are needed to verify the underpinning mechanisms to guide precise prevention.

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Publication Details

Journal
Journal of the American Heart Association
Published
2025-12-17
DOI
https://doi.org/10.1161/jaha.125.043446
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

APOE Genotype Modulates the Relationship of Stroke With Dementia Risk: Associations and Peripheral Clues for Biological Mechanisms

Chengfei Zhang, Yugong Feng, Lan Tan, Chen‐Chen Tan et al.
Journal of the American Heart Association
Dementia and Cognitive Impairment Research
article

APOE Genotype Modulates the Relationship of Stroke With Dementia Risk: Associations and Peripheral Clues for Biological Mechanisms

Chengfei Zhang, Yugong Feng, Lan Tan, Chen‐Chen Tan, Wei Xu, Lifan Huang
article en

Abstract

Stroke interacts with <i>APOE</i> ε4 to influence dementia, with the association being more pronounced in <i>APOE</i> ε4 non-carriers. Future studies are needed to verify the underpinning mechanisms to guide precise prevention.

Journal of the American Heart AssociationVol. 15(1)
Qingdao University (CN), Univerzitetni Rehabilitacijski Inštitut (SI), Affiliated Hospital of Qingdao University (CN), Qingdao Municipal Hospital (CN)
Openalex Percentile: Top 52%
Dementia and Cognitive Impairment Research
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