Endothelial Dysfunction Contributes to Chondrocyte Senescence Associated With Insulin‐Like Growth Factor‐Binding Protein‐6 in a Spontaneously Hypertensive Rat Model
Systemic vascular dysfunction may induce local joint damage with upregulation of endothelial IGFBPs secretion such as IGFBP6. This study highlights a potential therapeutic target for preventing joint structural damage by addressing endothelial dysfunction.
Authors
- Chunyi Wen (ORCID: https://orcid.org/0000-0003-1949-7822)
- Zongwei Cai (ORCID: https://orcid.org/0000-0002-8724-7684)
- Man Ting Au (ORCID: https://orcid.org/0000-0003-1786-6006)
- Karen Ching (ORCID: https://orcid.org/0000-0002-5031-6500)
- Lin Zhu (ORCID: https://orcid.org/0000-0002-2801-3626)
- Lanlan Zhang (ORCID: https://orcid.org/0000-0002-9306-1907)
- Sidney Yip (ORCID: https://orcid.org/0000-0002-2727-0137)
- Xin Lü (ORCID: https://orcid.org/0000-0002-6587-1152)
- Zhongyu Liu (ORCID: https://orcid.org/0000-0002-2016-2424)
- Yuqi Zhang (ORCID: https://orcid.org/0000-0002-3173-9364)
Institutions
- Hong Kong Baptist University (HK)
- Hong Kong Polytechnic University (HK)
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Southern University of Science and Technology (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1161/jaha.124.042132
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00