Lateral Parafacial Neurons Evoked Expiratory Oscillations Driving Neurogenic Hypertension
The heightened sympathetic activity inducing hypertension triggered by chronic intermittent hypoxia is caused, in the most part, by the emergence of pFL expiratory oscillations driving RVLM and A5 sympathetic vasomotor neurons and active expiration simultaneously. We propose that suppressing pFL neurons would have therapeutic potential.
Authors
- Karolyne S. Magalhães (ORCID: https://orcid.org/0000-0001-5755-6147)
- Benedito H. Machado (ORCID: https://orcid.org/0000-0001-5648-0929)
- Renato Willian Martins Sá (ORCID: https://orcid.org/0000-0001-9023-2777)
- Thaís Marques da Silva (ORCID: https://orcid.org/0000-0001-7570-8634)
- Nathalia Salim
- Davi J. A. Moraes (ORCID: https://orcid.org/0000-0001-6132-0217)
- Julian F.R. Paton (ORCID: https://orcid.org/0000-0002-7527-5493)
Institutions
- Universidade de São Paulo (BR)
- The Centre for Health (New Zealand) (NZ)
- Institute of Biomedical Science (GB)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1161/circresaha.125.326674
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 0.00