Discovery of globally rare CYP51 mutations associated with azole resistance in Iranian Zymoseptoria tritici isolates
This study documents the emergence of novel resistance-associated mutations in Iranian Z. tritici populations, expanding the spectrum of known CYP51 variants. The findings highlight the interplay between coding mutations, regulatory changes, and structural flexibility in shaping fungicide resistance. An integrated approach combining phenotypic assays, sequencing, expression analysis, and structural modelling provides a robust framework for monitoring resistance and informing sustainable fungicide use in wheat disease management.
Authors
- Debabrata Dutta (ORCID: https://orcid.org/0000-0002-6506-3032)
- Pablo Antonio Chong Aguirre
- Daniel Croll (ORCID: https://orcid.org/0000-0002-2072-380X)
- Naser Mohammadi (ORCID: https://orcid.org/0000-0002-6879-5642)
- Amir Mirzadi Gohari (ORCID: https://orcid.org/0000-0001-6147-4312)
- Ehssan Torabi (ORCID: https://orcid.org/0000-0003-1949-2554)
- Guido Puccetti (ORCID: https://orcid.org/0000-0002-7747-4306)
- Angela Feechan (ORCID: https://orcid.org/0000-0002-4954-5613)
- Alireza Monsef Esfehani
Institutions
- University College Dublin (IE)
- Escuela Superior Politecnica del Litoral (EC)
- University of Tehran (IR)
- Heriot-Watt University (GB)
- Agricultural Research & Education Organization (IR)
- University of Neuchâtel (CH)
Publication Details
- Journal
- BMC Plant Biology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s12870-025-07936-2
- Primary Topic
- Fungal Plant Pathogen Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00