Modular One-Step Three-Component Synthesis of Vinyl Ethers by Benzoquinone Trapping of Vinyl Radicals
We describe an iron/amine synergistically catalyzed three-component protocol for the synthesis of vinyl ethers containing pyridine units. This method uses oxime esters, enals, and benzoquinones as readily accessible substrates, affording the vinyl ethers in moderate to good yields and displaying good functional group compatibility.
Authors
- Kun Jiang (ORCID: https://orcid.org/0000-0003-3148-5058)
- Ye Wei (ORCID: https://orcid.org/0000-0001-9970-4152)
- Ning Yu
- Yuqiang Zhou
- Jia‐Hao Zhou (ORCID: https://orcid.org/0000-0001-8874-7405)
- Mei-Jun Zheng
- Lv-Yan Liu
Institutions
- Southwest University (CN)
- Chongqing Municipal Government (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1021/acs.orglett.5c04413
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00