Clinicopathological features of steroid-refractory immune-mediated hepatotoxicity induced by immune checkpoint inhibitors
This study is the first to demonstrate that cholangitis is more prominent in steroid-refractory IMH. MMF is a safe and effective second-line treatment, and its early induction should be considered in patients with histological evidence of cholangitis.
Authors
- Motoyuki Kohjima (ORCID: https://orcid.org/0000-0001-5285-3054)
- Yuki Azuma (ORCID: https://orcid.org/0000-0001-5028-5129)
- Tomonobu Hioki
- Koji Imoto (ORCID: https://orcid.org/0000-0003-4323-263X)
- Takeshi Goya (ORCID: https://orcid.org/0000-0001-9035-8695)
- Tomomi Aoyagi
- Yoshihiro Ogawa (ORCID: https://orcid.org/0000-0002-0834-2836)
- Atsushi Horiuchi
- Masaki Kato (ORCID: https://orcid.org/0000-0002-8017-7708)
- Masatake Tanaka (ORCID: https://orcid.org/0000-0001-7461-0678)
- Yoshinao Oda
- Motoi Takahashi
Institutions
- Kyushu University (JP)
- National Kyushu Medical Center (JP)
- Nakamura Gakuen University (JP)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s12876-025-04561-z
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00