Analytical Solutions for the Cardiac Extracellular‐Membrane‐Intracellular Model

ABSTRACT The cardiac extracellular‐membrane‐intracellular (EMI) model is a novel mathematical framework for cardiac electrophysiology simulations. The cardiac EMI model provides a more detailed description of the heart's electrical activity compared to traditional monodomain and bidomain models, potentially making it better‐suited for understanding the electrical dynamics of the heart under pathological conditions. In this paper, we derive and verify several analytical solutions for the cardiac EMI model. Specifically, we obtain a family of solutions for a single two‐dimensional cell in polar coordinates and for a pair of coupled three‐dimensional cells in spherical coordinates. To verify the analytical solutions, we conduct numerical experiments using the mortar finite element method combined with operator splitting. The results demonstrate that these analytical solutions are effective for verifying the accuracy of software that performs numerical simulations of the cardiac EMI model.

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Publication Details

Journal
Mathematical Methods in the Applied Sciences
Published
2025-12-17
DOI
https://doi.org/10.1002/mma.70409
Citations
1
Primary Topic
Cardiac electrophysiology and arrhythmias
Type
article
Field-Weighted Citation Impact
1.39
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article

Analytical Solutions for the Cardiac Extracellular‐Membrane‐Intracellular Model

Raymond J. Spiteri, Alexei F. Cheviakov, Carlos Ballesteros
1 citations
Mathematical Methods in the Applied Sciences
Cardiac electrophysiology and arrhythmias
1.39
article

Analytical Solutions for the Cardiac Extracellular‐Membrane‐Intracellular Model

Raymond J. Spiteri, Alexei F. Cheviakov, Carlos Ballesteros
article en
1 citations

Abstract

ABSTRACT The cardiac extracellular‐membrane‐intracellular (EMI) model is a novel mathematical framework for cardiac electrophysiology simulations. The cardiac EMI model provides a more detailed description of the heart's electrical activity compared to traditional monodomain and bidomain models, potentially making it better‐suited for understanding the electrical dynamics of the heart under pathological conditions. In this paper, we derive and verify several analytical solutions for the cardiac EMI model. Specifically, we obtain a family of solutions for a single two‐dimensional cell in polar coordinates and for a pair of coupled three‐dimensional cells in spherical coordinates. To verify the analytical solutions, we conduct numerical experiments using the mortar finite element method combined with operator splitting. The results demonstrate that these analytical solutions are effective for verifying the accuracy of software that performs numerical simulations of the cardiac EMI model.

Mathematical Methods in the Applied Sciences
University of Saskatchewan (CA)
Openalex Percentile: Top 13%
Cardiac electrophysiology and arrhythmias
1.39
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