Preoperative selection of best-fit imaging targets and image-guided surgery improves tumor delineation and surgical outcomes: a proof-of-concept study

This proof-of-concept study demonstrates that tumor biology-based molecular imaging is feasible and can accurately delineate tumor boundaries. Preoperative analysis allows for the selection of optimal imaging targets with high SBRs, potentially enhancing surgical precision. However, its generalizability and clinical relevance require validation across multiple tumor models with sufficient sample size, extended follow-up, and clinical studies.