Pancreatic dysfunction causally impacts region-specific cortical thinning: a Mendelian randomization study revealing pancreas–brain axis
These findings provide MR evidence supporting a potential causal link between pancreatic diseases and cerebral cortex morphology. Our findings suggest that malignant pancreatic cancer has a causal effect on the structure of the cerebral cortex, suggesting the existence of a "pancreas-brain axis" mechanism.
Authors
- Yaqi Sun (ORCID: https://orcid.org/0000-0002-1287-1706)
- Jiali Mao
- Hongxia Wu (ORCID: https://orcid.org/0000-0001-7209-2109)
- Hanbin Wang (ORCID: https://orcid.org/0009-0007-9650-0745)
- Liang Yu (ORCID: https://orcid.org/0000-0003-1667-5427)
- Di Zhang (ORCID: https://orcid.org/0000-0002-2342-5779)
- Yang Yang (ORCID: https://orcid.org/0009-0004-2074-3589)
- Wei Hu (ORCID: https://orcid.org/0000-0001-7113-9040)
- Jianliang Sun (ORCID: https://orcid.org/0000-0001-9796-7370)
- Zhipeng Xu (ORCID: https://orcid.org/0000-0002-6661-5572)
- Weiyan Zhang
- Xu Qiu
Institutions
- Zhejiang Chinese Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Westlake University (CN)
- Children's Hospital of Zhejiang University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1097/js9.0000000000004132
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00