CEBPD-mediated SGPP2 upregulation via PERK/ER stress in endothelial cells disrupts S1P homeostasis and impairs angiogenesis in chronic endometritis
Our findings delineate a novel pathway linking inflammatory stress to aberrant angiogenesis in endometrium, in which ER stress-driven CEBPD activation transcriptionally upregulates SGPP2, creating a molecular nexus between inflammation and sphingolipid metabolism. This S1P signaling deficit compromises a critical angiogenic pathway necessary for vascular remodeling, which in turn disrupts endometrial receptivity and contributes to CE-associated reproductive failures.
Authors
- Xiaoyan Chen (ORCID: https://orcid.org/0000-0003-3719-6601)
- Lianghui Diao (ORCID: https://orcid.org/0000-0002-1159-9261)
- Gene Jiing‐Yun You (ORCID: https://orcid.org/0000-0002-6417-5817)
- Ruochun Lian (ORCID: https://orcid.org/0009-0007-3941-9270)
- Shuyi Yu (ORCID: https://orcid.org/0000-0001-7536-6099)
- Yuye Li (ORCID: https://orcid.org/0009-0008-3328-5002)
- Tailang Yin (ORCID: https://orcid.org/0000-0003-2032-0901)
- Cong Chen (ORCID: https://orcid.org/0000-0003-0875-7473)
- Yanjun Wang (ORCID: https://orcid.org/0000-0001-5513-0177)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Shenzhen Zhongshan Urological Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s12967-025-07558-0
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00