Apoptotic extracellular vesicles from peripancreatic adipose-derived mesenchymal stem cells ameliorate severe acute pancreatitis through the transcription factor EB-mediated autophagy–lysosomal pathway: an experimental study
Given the high yield and ease of obtaining ApoEVs from P-ADSCs, our findings underscore the significant therapeutic potential of ApoEVs from dying P-ADSCs in treating SAP, highlighting their broad relevance for cell-free therapeutic approaches.
Authors
- Wenbin Hou (ORCID: https://orcid.org/0000-0001-6527-975X)
- Yanli Li (ORCID: https://orcid.org/0000-0002-2936-0339)
- Zhengwei Tu (ORCID: https://orcid.org/0000-0002-5009-0695)
- Wenfeng Gou (ORCID: https://orcid.org/0000-0002-4828-4298)
- Yunfeng Cui (ORCID: https://orcid.org/0000-0001-6415-0321)
- Cong Wang (ORCID: https://orcid.org/0009-0002-4450-5126)
- Xuefei Wang (ORCID: https://orcid.org/0000-0003-3976-4908)
- Ao Wang (ORCID: https://orcid.org/0000-0003-2137-7029)
- Yu An (ORCID: https://orcid.org/0000-0001-8051-8229)
- Feifei Xu (ORCID: https://orcid.org/0000-0002-2162-5590)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Tianjin Nankai Hospital (CN)
- Tianjin Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1097/js9.0000000000004555
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00