Graphene for self-powered biosensors: a perspective

Graphene-based self-powered sensors are emerging as a powerful solution for real-time health-monitoring and autonomous sensing systems. Owing to graphene's exceptional electrical conductivity, flexibility and biocompatibility, these sensors can function without external power, drawing energy from mechanical, thermal or biochemical sources. This perspective highlights key advancements in energy-harvesting strategies, including triboelectric and piezoelectric nanogenerators (TENGs and PENGs), as well as biofuel cells (BFCs), where graphene significantly enhances charge transfer and power output. The integration of graphene into nanocomposite architectures through scalable techniques such as pressure spinning improves surface area, sensing efficiency and manufacturability. Functional modifications using metal nanoparticles and conducting polymers have further advanced sensor stability and specificity, enabling accurate biomarker detection in complex biological human body fluids. Practical implementations in wearable electronics, implantable devices and smart environmental systems demonstrate the real-world impact of these innovations. The role of graphene-based materials extends beyond healthcare into robotics and soft electronics, where its properties support the development of self-powered, skin-like interfaces. As research continues to address scalability, long-term stability and miniaturization, graphene-based biosensors are expected to become central components in next-generation bioelectronic platforms. This article provides a forward-looking perspective on how graphene is shaping the future of autonomous, intelligent and user-centred sensing technologies.