Lactate attenuates PANoptosis and enhances ZBP-1 lactylation in macrophages in acute lung injury
The present study revealed the regulatory role of lactate in inflammation and cell death in ALI and suggested a lactylation-associated therapeutic strategy for ALI.
Authors
- Jie Huang (ORCID: https://orcid.org/0000-0002-1945-6353)
- Zhengyu Jiang (ORCID: https://orcid.org/0000-0002-4788-9068)
- Zhefan Wang (ORCID: https://orcid.org/0009-0009-1404-936X)
- Yehao Chen
- Yizhuo Zhang (ORCID: https://orcid.org/0000-0002-6128-3476)
- Xiao Yang (ORCID: https://orcid.org/0000-0002-7823-745X)
- Jinxiang Yin
- Z. Wang (ORCID: https://orcid.org/0009-0009-0990-8860)
- Dan Wang (ORCID: https://orcid.org/0000-0003-4154-9617)
- Yi Gong
Institutions
- Naval Medical Research Command (US)
- Second Military Medical University (CN)
- Shanghai Changzheng Hospital (CN)
- Changhai Hospital (CN)
- Shanghai Jinyuan Senior High School (CN)
- Yangpu Hospital of Tongji University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1648303
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00