Monocyte Activation in People With HIV and Tuberculosis Coinfection and Effect of Tuberculosis Preventive Therapy: An Analysis of the ACTG A5279/BRIEF TB Trial
PWH with a positive TST or IGRA exhibited signals of monocyte activation pre- and post-TPT. TPT with 1HP led to blunted proinflammatory monocyte changes compared with 9H.
Authors
- Amita Jain Gupta (ORCID: https://orcid.org/0000-0001-7036-2718)
- Kristine Mace Erlandson (ORCID: https://orcid.org/0000-0003-0808-6729)
- Carl J. Fichtenbaum (ORCID: https://orcid.org/0000-0002-6778-7253)
- Manuel G. Feria (ORCID: https://orcid.org/0000-0001-8569-0343)
- Xinyu Du (ORCID: https://orcid.org/0009-0005-4768-4109)
- Khuanchai Supparatpinyo (ORCID: https://orcid.org/0000-0003-1838-4826)
- Ashley McKhann
- Susan Swindells (ORCID: https://orcid.org/0000-0001-5826-6037)
- Michelle A. Kendall (ORCID: https://orcid.org/0000-0001-9160-4544)
- Moises Arturo Huaman (ORCID: https://orcid.org/0000-0002-6839-5809)
- Netanya S. Utay (ORCID: https://orcid.org/0000-0002-6407-8670)
- Claire Chougnet
- Richard E. Chaisson (ORCID: https://orcid.org/0000-0003-4710-925X)
- Michael M. Lederman (ORCID: https://orcid.org/0000-0001-9247-8025)
- Frederick K. Sawe
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Southwestern Medical Center (US)
- Cancer Research And Biostatistics (US)
- Reed Medical (United Kingdom) (GB)
- Chiang Mai University (TH)
- Case Western Reserve University (US)
- University of Nebraska Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
- University of Cincinnati Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1093/ofid/ofaf771
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00