WNT10A-SMOC2-LRP4 network affects permanent tooth development via potential tooth-bone interaction
Based on a case of NSTA with SMOC2 and novel LRP4 variations linked to tooth agenesis and bone development, we revealed that LRP4 + alveolar bone cells may influence tooth development through FGF signaling, thereby regulating WNT10A + and SMOC2 + dental pulp cells.
Authors
- Xuechun Li (ORCID: https://orcid.org/0000-0003-2175-8307)
- Yiting Liu (ORCID: https://orcid.org/0000-0002-7704-2802)
- Xiaoshan Wu (ORCID: https://orcid.org/0000-0002-7003-0884)
- Siyuan Ma
- Qingping Gao (ORCID: https://orcid.org/0000-0003-0488-3130)
- Jing Sun (ORCID: https://orcid.org/0009-0007-2335-322X)
- Yi Wu (ORCID: https://orcid.org/0000-0002-8823-2134)
- Yiqi Chen (ORCID: https://orcid.org/0009-0008-1808-0500)
- Caiqi Zhang
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s12903-025-06451-y
- Primary Topic
- dental development and anomalies
- Type
- article
- Field-Weighted Citation Impact
- 0.00