Deciphering bisphenol A (BPA)-elicited osteoarthritis mechanisms through network toxicology and molecular docking, then de novo generation of novel therapeutic candidates
This study elucidates BPA's molecular mechanisms in OA and identifies promising therapeutic candidates. The integration of network toxicology, molecular docking, and computational drug discovery provides a robust framework for understanding environmental toxicants and advancing OA therapies.
Authors
- Zhichun Huang (ORCID: https://orcid.org/0000-0003-4944-3614)
- Ram Samudrala (ORCID: https://orcid.org/0000-0001-9069-8497)
- Zackary Falls (ORCID: https://orcid.org/0000-0003-4116-0441)
- Zhuo Zhang (ORCID: https://orcid.org/0009-0008-0083-3666)
- Zhi‐Rong Tan (ORCID: https://orcid.org/0000-0002-0420-6298)
- Liping Jiang (ORCID: https://orcid.org/0000-0002-1785-7225)
- Huilan Wu
- Sumei Xu (ORCID: https://orcid.org/0000-0002-0297-7208)
- Xin Luo (ORCID: https://orcid.org/0000-0002-1740-2765)
- Wu Wei (ORCID: https://orcid.org/0000-0003-0830-0289)
Institutions
- Central South University (CN)
- Ministry of Education (SA)
- National Clinical Research (US)
- PharmacoGenetics (China) (CN)
- Xiangya Hospital Central South University (CN)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s40360-025-01069-w
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.00