Refining MASLD Phenotypes: Clinical, Metabolic, and Elastographic Differences Between Adipose Tissue Dysfunction and Obesity-Driven Disease
MASLD progression appears to follow two complementary but distinct mechanisms: an inflammatory, adipose dysfunction pathway dominated by IL-6 activation and early anabolic decline, and a metabolic-overload pathway driven by obesity. Phenotype-specific evaluation integrating inflammatory markers, metabolic indices, and elastographic parameters may improve risk stratification and inform personalized therapeutic strategies.
Authors
- Alin Grosu
- Valer Donca (ORCID: https://orcid.org/0000-0003-0231-2131)
- Lucreţia Avram (ORCID: https://orcid.org/0000-0003-2656-3234)
- Dana Crişan (ORCID: https://orcid.org/0000-0002-1627-9670)
- Andrei Mihai Bălan (ORCID: https://orcid.org/0000-0003-0038-7084)
- Elena Buzdugan (ORCID: https://orcid.org/0000-0002-2992-6056)
- Laurenţiu Stoicescu (ORCID: https://orcid.org/0000-0001-7451-1901)
- Andrada Nemeş (ORCID: https://orcid.org/0000-0002-0600-6097)
- Tudor Cosma (ORCID: https://orcid.org/0009-0005-7626-1869)
Institutions
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Institutul Regional de Gastroenterologie Prof. Dr. Octavian Fodor (RO)
Publication Details
- Journal
- Nutrients
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3390/nu17243940
- Citations
- 1
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.35