Hyodeoxycholic Acid Suppresses High-Fat-Diet–Promoted MC38-Syngeneic Colorectal Tumor Growth via Bile Acid Remodeling and Microbiota Modulation
HDCA intake ameliorates HFD-induced obesity phenotype, inhibiting colorectal tumor growth in mice, and decreases the abundance of gut microbiota. Gut microbiota affected by HDCA may participate in metabolism-related effects through circulation, which might be one way that HDCA affects colorectal tumors.
Authors
- Ningxin Chen (ORCID: https://orcid.org/0009-0003-8435-3160)
- Jinhua Lin
- Shankuan Zhu (ORCID: https://orcid.org/0000-0002-9509-7364)
- Congcong Wang (ORCID: https://orcid.org/0000-0002-1330-9483)
- Fei Yang (ORCID: https://orcid.org/0000-0003-0571-2798)
- Meng Duan
- Wei He (ORCID: https://orcid.org/0000-0001-5801-9044)
- Ya‐Ting Yang (ORCID: https://orcid.org/0009-0008-9735-2403)
- Yuwen Shi (ORCID: https://orcid.org/0009-0004-5932-0698)
- Jialing He (ORCID: https://orcid.org/0000-0002-2478-6779)
- Simayi Halizere
Institutions
- Children's Hospital of Zhejiang University (CN)
- Zhejiang Institute of Mechanical and Electrical Engineering (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3390/nu17243939
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00