Antihyperglycemic Effect of Novel Pyridazinone Derivative on the Alloxan-Induced Diabetes Model in Rats

Type 2 diabetes mellitus represents a significant and escalating global health concern. Projections estimate that the number of individuals living with diabetes will increase dramatically, rising from 425 million in 2017 to approximately 629 million by 2045. While available antidiabetic medications are effective, their use is frequently accompanied by adverse effects, including low blood sugar and digestive disturbances, underscoring the need for safer alternatives. Pyridazinones, a class of six-membered nitrogen-containing heterocycles with adjacent nitrogen atoms, have emerged as promising scaffolds in medicinal chemistry. Specifically, pyridazine-3-one, which features a carbonyl group at the third position, is recognized for its wide spectrum of biological activities. By introducing a benzoxazole ring onto the pyridazinone framework, researchers aim to enhance and explore novel antidiabetic properties in these derivatives. Thus, the novel compound 1-(5-chloro-1,3-benzoxazol-2-yl)-4-methyl-1,2-dihydropyridazine-3,6-dione has been synthesized and is proposed for evaluation as a potential antidiabetic agent. Keywords: Diabetes mellitus, Pyridazinone, Benzoxazole