Genetic liability to psoriasis predicts severe disease outcomes

The psoriasis susceptibility PRS demonstrates utility and may be more effective than established epidemiological factors, as a stratification tool to identify those individuals that are at greatest risk of severe disease and may benefit most from early intervention.

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Journal
Genome Medicine
Published
2025-12-17
DOI
https://doi.org/10.1186/s13073-025-01561-2
Primary Topic
Psoriasis: Treatment and Pathogenesis
Type
article
Field-Weighted Citation Impact
0.00

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article

Genetic liability to psoriasis predicts severe disease outcomes

Karol Estrada, Terttu Harju, Sinéad Langan, Tero Hiekkalinna et al.
Genome Medicine
Psoriasis: Treatment and Pathogenesis
article

Genetic liability to psoriasis predicts severe disease outcomes

Karol Estrada, Terttu Harju, Sinéad Langan, Tero Hiekkalinna, Jaakko A. Kaprio, Rachel Wachsmuth, Marc Jung, Katri Kaukinen, Sami Koskelainen, Rajan P. Nair, Mikko Kiviniemi, Manju Kalavala, Annika Auranen, Fredrik O. Åberg, Katya Burova, Külli Kingo, Robert Graham, Tuula Palotie, Leila Ferguson, Antti A. Mäkitie, Antti Palomäki, Bernadette DeSilva, Nicole Lawson, Sanna Siltanen, Fiona Antony, Victoria Brown, Philip E. Stuart, Periasamy Balasubramaniam, Outi Uimari, Kimmo Palin, Sarah M. Johnson, Teea Salmi, Tiina Hannele Luukkaala, Sandro Bruno, Oskari Heikinheimo, Masahiro Kanai, Maarit Niinimäki, Tuomo J Meretoja, Regis Wong, Ulvi Kahraman Gürsoy, Leena Koulu, Debby Ngo, Lotta Männikkö, James T. Elder, Vincent Llorens, Sauli Vuoti, Roosa Kallionpää, Rigbe Weldatsadik, Khader Shameer, Antti Hakanen, Kavitha Sundararaj, Mitja Kurki, Jani T. Tikkanen, Venla Kurra, S. Cliff, Jaakko Tyrmi, Joni A. Turunen, Veikko Salomaa, George Okafo, Samuel Lessard, Jonathan H. Chung, Markus Perola, Katariina Hannula‐Jouppi, John Bowes, Katja Kivinen, Juulia Partanen, Laura Addis, Kati Kristiansson, Auli Toivola, Kai Kaarniranta, Minna K. Karjalainen, Dirk S. Paul, Johannes Kettunen, Päivi Laiho, Ulrike Hüffmeier, Sarah Walsh, Nan Bing, Laura Huilaja, Rebecca Rose, Anne C Barton, Tuuli Sistonen, Dermot F. Reilly, Rodos Rodosthenous, Varpu Jokimaa, Calum C. Lyon, Katie Watts, Katriina Aalto‐Setälä, Nick J. Levell, Simonne Longerich, Jukka Peltola, Ravi Ramessur, Tanel Traks, Lauri A. Aaltonen, Trupti Desai, Päivi Auvinen, Zhihao Ding, Minna Raivio, Riitta Lahesmaa, Caroline Owen, Teijo Kuopio, Olli Carpén, Kati Hyvärinen, Katri Pylkäs, Aoxing Liu, Sami Heikkinen, Joanna Betts, Hubert Chen, Kati Donner, Anna Vlahiotis, Argyro Bizaki-Vallaskangas, Edmond Teng, Erkki Isometsä, Riikka K. Arffman, Henrike Heyne, Jennifer L. Schutzman, Nabil Ponnambath, Vuokko Anttonen, Rasko Leinonen, Elina Kilpeläinen, Urvi Popli, Airi Jussila, Chris O ́Donnell, Michael A. 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article en

Abstract

The psoriasis susceptibility PRS demonstrates utility and may be more effective than established epidemiological factors, as a stratification tool to identify those individuals that are at greatest risk of severe disease and may benefit most from early intervention.

Genome MedicineVol. 18(1)
Novartis (Switzerland) (CH), Memorial University of Newfoundland (CA), Target (United States) (US), NHS Lothian (GB), University Health Network (CA), Murdoch University (AU), University of Dundee (GB), University of California, San Francisco (US), King's College London (GB), Norwegian University of Science and Technology (NO), University of Michigan (US), Oulu University Hospital (FI), Toronto Western Hospital (CA), Tartu University Hospital (EE), Edinburgh Cancer Research (GB), University of Manchester (GB), Christian-Albrechts-Universität zu Kiel (DE), University of Bristol (GB), Universitätsklinikum Erlangen (DE), London School of Hygiene & Tropical Medicine (GB), Manchester University NHS Foundation Trust (GB), St Olav's University Hospital (NO), Sanofi (United States) (US), Arthritis UK (GB), Perron Institute for Neurological and Translational Science (AU), Nexus Clinical Research (Canada) (CA), Genomics (United Kingdom) (GB), NIHR Manchester Biomedical Research Centre (GB), Avenir Health (US), Krembil Research Institute, University of Tartu (EE)
Bristol-Myers Squibb, Pfizer, AstraZeneca, GlaxoSmithKline, Sanofi, Biogen, Celgene, Norges Teknisk-Naturvitenskapelige Universitet, School of Public Health, University of Michigan, European Federation of Pharmaceutical Industries and Associations, Maze Therapeutics, National Institute for Health and Care Research, British Association of Dermatologists, King's College London, European Commission, King's Health Partners, Helse Midt-Norge, Norges Forskningsråd, Business Finland, National Institutes of Health, Genentech, Medical School, University of Michigan, Novartis Pharma, Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet, Faculty of Medicine and Health, University of Sydney, Norwegian Institute of Public Health, Janssen Biotech
Openalex Percentile: Top 54%
Psoriasis: Treatment and Pathogenesis
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