Voxel-based dosimetry for predicting treatment response to transarterial radioembolization in hepatocellular carcinoma: significance of intratumoral dose distribution
Voxel-based dosimetry using multiple VSV kernels enables quantitative assessment of intratumoral dose distribution in HCC patients treated with TARE. Among voxel-level parameters, D70, V-V<sub>205</sub>, and CoV showed good performance in predicting CR, and V-V<sub>205</sub> was the only independent predictor for both treatment response and L-PFS. These findings support the added prognostic value of voxel-based dose metrics beyond average tumor absorbed dose.
Authors
- Minseok Suh (ORCID: https://orcid.org/0000-0002-6932-8552)
- Jin Woo Choi (ORCID: https://orcid.org/0000-0002-6639-8002)
- Hyo‐Cheol Kim (ORCID: https://orcid.org/0000-0002-6016-247X)
- Keon Min Kim (ORCID: https://orcid.org/0000-0003-1634-8215)
- Jin Chul Paeng (ORCID: https://orcid.org/0000-0002-7464-9342)
- Jae Sung Lee (ORCID: https://orcid.org/0000-0001-7623-053X)
Institutions
- Seoul National University (KR)
- New Generation University College (ET)
- National University College (PR)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s40658-025-00822-8
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00