Dapagliflozin and chiglitazar combination enhanced myocardial energy metabolism in high‐fat diet‐fed mice
The combination of dapagliflozin and chiglitazar improved cardiac fatty acid and central carbon metabolism, among which acceleration of metabolic flux through the TCA cycle, increased ATP production, and upregulation of key enzyme expression might represent the key beneficial mechanisms.
Authors
- Ziyan Xie (ORCID: https://orcid.org/0000-0002-1728-5001)
- Jing Liu (ORCID: https://orcid.org/0000-0002-3311-0818)
- Shunhua Li (ORCID: https://orcid.org/0000-0002-9625-9724)
- Mengyu He (ORCID: https://orcid.org/0000-0002-0997-8414)
- Miao Yu (ORCID: https://orcid.org/0000-0003-1450-9011)
- Xue-Mei Ma
- Xinhua Xiao (ORCID: https://orcid.org/0000-0001-5441-7766)
- Jieying Liu (ORCID: https://orcid.org/0000-0001-9041-3834)
- Dongmei Wang (ORCID: https://orcid.org/0000-0002-0890-0113)
- Jing Zhou (ORCID: https://orcid.org/0000-0003-4076-4083)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1111/dom.70327
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00