Differential regulation of radioadaptation by quercetin between human normal and cancer cells
Quercetin selectively enhances radioadaptation in normal cells by activating antioxidant pathways and reducing DNA damage, while preserving or amplifying radiosensitivity in cancer cells. These findings support quercetin may serve as a potential radiomodulating agent with favorable safety for increasing the therapeutic window of radiotherapy.
Authors
- Rianne Biemans (ORCID: https://orcid.org/0000-0002-9300-0768)
- Ludwig J. Dubois (ORCID: https://orcid.org/0000-0002-8887-4137)
- Xiaojun Li (ORCID: https://orcid.org/0000-0002-5530-1666)
- Mingyu Zhang (ORCID: https://orcid.org/0000-0001-7907-3971)
- Rui Zhang (ORCID: https://orcid.org/0000-0002-7779-8722)
- Chujie Li (ORCID: https://orcid.org/0000-0002-3362-072X)
Institutions
- Hainan University (CN)
- Maastricht University (NL)
- Zhongshan Hospital (CN)
- Maastro Clinic (NL)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1016/j.ctro.2025.101099
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Scholarship Council