HIV-1 virologic failure in the RESINA cohort: lessons from two decades of real-world data
VF was uncommon and declined over time, reflecting improved regimen potency and tolerability. Failures were associated with late presentation and IDU, consistent with adherence barriers. Resistance often involved multiple classes, while INSTI resistance remained infrequent. Early, genotype-guided optimization, preferably to INSTI-based therapy, combined with targeted adherence support may improve outcomes.
Authors
- Heribert Knechten
- Tom Luedde (ORCID: https://orcid.org/0000-0002-6288-8821)
- Mark Oette
- Eva Heger (ORCID: https://orcid.org/0000-0001-7625-5139)
- Niels Schübel
- Lila Haberl (ORCID: https://orcid.org/0000-0002-1286-3765)
- Joachim Büch (ORCID: https://orcid.org/0000-0003-3534-9512)
- Falk Hüttig
- Björn‐Erik Ole Jensen (ORCID: https://orcid.org/0000-0003-1626-4855)
- Jörg Timm (ORCID: https://orcid.org/0000-0001-7799-3045)
- Jürgen Kurt Rockstroh (ORCID: https://orcid.org/0000-0003-2858-3888)
- Katja Römer
- Clara Lehmann (ORCID: https://orcid.org/0000-0002-7042-1578)
- Martin Hower (ORCID: https://orcid.org/0000-0001-5967-5238)
- Nadine Lübke (ORCID: https://orcid.org/0000-0003-3820-7915)
- Stephan M. Schneeweiß
- Rolf Kaiser (ORCID: https://orcid.org/0000-0002-2640-2548)
- Stefan Eßer (ORCID: https://orcid.org/0000-0002-3625-9650)
- Smaranda Gliga (ORCID: https://orcid.org/0000-0001-8191-504X)
- Michael Böhm (ORCID: https://orcid.org/0000-0003-1208-8647)
- Alexander Killer (ORCID: https://orcid.org/0009-0004-8427-0266)
- Claudia Müller (ORCID: https://orcid.org/0009-0009-2517-6022)
- Gerd Fätkenheuer
- Nazifa Qurishi
Institutions
- University of Cologne (DE)
- University Hospital Bonn (DE)
- Düsseldorf University Hospital (DE)
- Krankenhaus der Augustinerinnen (DE)
- German Center for Infection Research (DE)
- Essen University Hospital (DE)
- Klinikum Dortmund (DE)
- Klinikum Osnabrück (DE)
- University Hospital Cologne (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Duisburg-Essen (DE)
- FH Aachen (DE)
Publication Details
- Journal
- Infection
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1007/s15010-025-02713-7
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00