Prognostic significance of O6-methylguanine-DNA methyltransferase promoter methylation status in isocitrate dehydrogenase-mutant glioma

MGMTp methylation was not associated with a prognostic or predictive value in our IDH-mutant glioma cohort. CDKN2A/B status and extent of resection were strong predictors of outcomes.

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Publication Details

Journal
Neuro-Oncology
Published
2025-12-13
DOI
https://doi.org/10.1093/neuonc/noaf287
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Prognostic significance of O6-methylguanine-DNA methyltransferase promoter methylation status in isocitrate dehydrogenase-mutant glioma

L. Nicolas Gonzalez Castro, Tamar R. Berger, Julie J. Miller, John Yohan Rhee et al.
Neuro-Oncology
Glioma Diagnosis and Treatment
article

Prognostic significance of O6-methylguanine-DNA methyltransferase promoter methylation status in isocitrate dehydrogenase-mutant glioma

L. Nicolas Gonzalez Castro, Tamar R. Berger, Julie J. Miller, John Yohan Rhee, Patrick Yung Wen, Isabel Arrillaga‐Romany, Gilbert Youssef, Aleksandra B Lasica, J Ricardo McFaline-Figueroa, Zhou Lan, Eudocia Q. Lee, Vihang Nakhate, Elisa Aquilanti, Rameen Beroukhim, Jörg Dietrich, Ugonma Nnenna Chukwueke, Justin T. Jordan, Scott Randall Plotkin, David A. Reardon, Tracy T. Batchelor, Lakshmi Nayak, Juan Pablo Ospina, Deborah Anne Forst, Elizabeth Robins Gerstner, Nancy Wang
article en

Abstract

MGMTp methylation was not associated with a prognostic or predictive value in our IDH-mutant glioma cohort. CDKN2A/B status and extent of resection were strong predictors of outcomes.

Neuro-Oncology
Brigham and Women's Hospital (US), Harvard University (US), NYU Langone Health (US), Massachusetts General Hospital (US), Center for Neuro-Oncology (US), Dana-Farber Cancer Institute (US), New York University (US)
Openalex Percentile: Top 39%
Glioma Diagnosis and Treatment
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