Prognostic significance of O6-methylguanine-DNA methyltransferase promoter methylation status in isocitrate dehydrogenase-mutant glioma
MGMTp methylation was not associated with a prognostic or predictive value in our IDH-mutant glioma cohort. CDKN2A/B status and extent of resection were strong predictors of outcomes.
Authors
- L. Nicolas Gonzalez Castro (ORCID: https://orcid.org/0000-0001-7699-5188)
- Tamar R. Berger
- Julie J. Miller (ORCID: https://orcid.org/0000-0002-1288-593X)
- John Yohan Rhee (ORCID: https://orcid.org/0000-0002-2081-5667)
- Patrick Yung Wen (ORCID: https://orcid.org/0000-0002-0774-7700)
- Isabel Arrillaga‐Romany (ORCID: https://orcid.org/0000-0001-5951-1225)
- Gilbert Youssef (ORCID: https://orcid.org/0000-0001-6109-7692)
- Aleksandra B Lasica (ORCID: https://orcid.org/0000-0002-9739-5103)
- J Ricardo McFaline-Figueroa (ORCID: https://orcid.org/0000-0002-6670-1841)
- Zhou Lan
- Eudocia Q. Lee (ORCID: https://orcid.org/0000-0003-3355-5179)
- Vihang Nakhate (ORCID: https://orcid.org/0000-0002-2941-9740)
- Elisa Aquilanti (ORCID: https://orcid.org/0000-0002-1343-5017)
- Rameen Beroukhim (ORCID: https://orcid.org/0000-0001-6303-3609)
- Jörg Dietrich (ORCID: https://orcid.org/0000-0001-8291-0136)
- Ugonma Nnenna Chukwueke (ORCID: https://orcid.org/0000-0003-0598-9535)
- Justin T. Jordan (ORCID: https://orcid.org/0000-0001-6198-817X)
- Scott Randall Plotkin (ORCID: https://orcid.org/0000-0002-6109-6419)
- David A. Reardon (ORCID: https://orcid.org/0000-0001-6674-0157)
- Tracy T. Batchelor (ORCID: https://orcid.org/0000-0001-7568-6607)
- Lakshmi Nayak
- Juan Pablo Ospina (ORCID: https://orcid.org/0000-0003-0556-6364)
- Deborah Anne Forst (ORCID: https://orcid.org/0000-0002-8428-0841)
- Elizabeth Robins Gerstner (ORCID: https://orcid.org/0000-0003-2382-3838)
- Nancy Wang (ORCID: https://orcid.org/0000-0001-7623-1858)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- NYU Langone Health (US)
- Massachusetts General Hospital (US)
- Center for Neuro-Oncology (US)
- Dana-Farber Cancer Institute (US)
- New York University (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1093/neuonc/noaf287
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00