Human urine-derived stem cells alleviate psoriasis by suppressing JAK2/STAT3 pathway-mediated macrophage polarization
Our data demonstrated that hUSCs remarkably ameliorated psoriasis by suppressing M1 and promoting M2 macrophage polarization through they-derived TGF-β1 inhibiting the JAK2/STAT3 pathway. Our results have revealed the molecular mechanism of hUSCs in treating psoriasis, highlighting a safe and effective cellular treatment method for psoriasis.
Authors
- Youqiong Zhuo
- Ke‐Yu Deng (ORCID: https://orcid.org/0000-0002-3519-6846)
- Xie Wei (ORCID: https://orcid.org/0000-0002-9396-3337)
- Hao‐Cheng Gu
- Lingfang Wang (ORCID: https://orcid.org/0000-0002-9002-3657)
- Zhou-Hang Zhang
- Hong-Bo Xin
- Qiming Huang
- Dilnuer Tula
Institutions
- Nanchang University (CN)
- State Key Laboratory of Food Science and Technology (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s13287-025-04870-w
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00