Screening for lung fibrosis using serum surfactant protein-D, KL-6, and a deep learning algorithm on chest radiographs: a prospective observational study
SP-D and KL-6 may be useful screening biomarkers for lung fibrosis in health checkup settings, offering high sensitivity and moderate positivity rates. BMAX also appears promising as a standalone screening tool for detecting lung fibrosis on chest radiographs.
Authors
- Hirotaka Nishikiori (ORCID: https://orcid.org/0000-0002-0573-9344)
- Haruka Takenaka (ORCID: https://orcid.org/0000-0002-2379-3707)
- Yuki Mori (ORCID: https://orcid.org/0000-0002-9320-826X)
- Hirofumi Chiba (ORCID: https://orcid.org/0000-0002-7033-3084)
- Ken-ichi Hirota
- Shinichiro Ueda (ORCID: https://orcid.org/0000-0001-8133-9361)
- Atsushi Saito (ORCID: https://orcid.org/0000-0003-3430-884X)
- Koji Kuronuma (ORCID: https://orcid.org/0000-0002-2743-3266)
- Masamitsu Hatakenaka (ORCID: https://orcid.org/0000-0002-4589-1578)
- Naoya Yama (ORCID: https://orcid.org/0000-0003-4810-2906)
- Mamoru Takahashi (ORCID: https://orcid.org/0000-0003-1630-8571)
- Ippei Neriai
Institutions
- Sapporo Medical University (JP)
- University of the Ryukyus (JP)
Publication Details
- Journal
- BMC Pulmonary Medicine
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s12890-025-04062-5
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00