Identification and functional analysis of hub genes in knee osteoarthritis via bioinformatics and experimental validation
This study identified key pathogenic genes and their regulatory pathways in KOA, highlighting their potential role in disease progression via inflammation and immune modulation. These findings provide insights for developing targeted therapeutic strategies for KOA.
Authors
- Junxian Gao (ORCID: https://orcid.org/0000-0002-1015-7103)
- Jianshu Lu
- Yue Song (ORCID: https://orcid.org/0000-0002-8943-1530)
- Baoen Jiang (ORCID: https://orcid.org/0000-0001-9279-014X)
- Shanyong Jiang
- Jingjing Cao (ORCID: https://orcid.org/0000-0003-4931-8717)
- Lianxin Li (ORCID: https://orcid.org/0000-0001-5771-9241)
- Jianxiao Liang
Institutions
- Wenzhou Medical University (CN)
- Shandong Provincial Hospital (CN)
- Dongyang People's Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioinformatics
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fbinf.2025.1671693
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00