Efficacy of polyethylene glycol in the treatment of spinal cord injury and its effect on inflammatory response and oxidative stress factors

The findings of this study demonstrate that PEG, as a fusogen, exhibits significant neuroprotective and regenerative effects when applied immediately after SCI. PEG not only attenuated oxidative stress and neuroinflammation but also preserved axonal integrity, promoted myelin protection, and enhanced functional recovery. These results suggest that early application of PEG represents an innovative and promising therapeutic strategy for SCI, warranting further investigation into its long-term efficacy and potential clinical translation.