Keratinocytes as active regulators of cutaneous and mucosal immunity: a systematic review across inflammatory epithelial disorders
This systematic review highlights keratinocytes as active regulators rather than passive bystanders in epithelial injury disorders. By integrating diverse inflammatory cues, keratinocytes engage shared and disease-specific pathways that shape immune responses across the spectrum of cutaneous and mucosal inflammation.
Authors
- Yizhuo Shen (ORCID: https://orcid.org/0000-0003-4453-0719)
- Bohdan Pomahač (ORCID: https://orcid.org/0000-0003-3703-8240)
- Gëorge F. Murphy (ORCID: https://orcid.org/0000-0001-9362-5146)
- Stav Brown (ORCID: https://orcid.org/0000-0003-4060-4450)
- Henry C. Hsia (ORCID: https://orcid.org/0000-0001-8674-9140)
- Martin Kauke‐Navarro (ORCID: https://orcid.org/0000-0001-5399-4166)
- Federico Repetto (ORCID: https://orcid.org/0009-0007-2792-3955)
- Christine J. Ko (ORCID: https://orcid.org/0000-0003-2270-2524)
- Nebal Abu Hussein (ORCID: https://orcid.org/0000-0001-6735-8435)
- Taylor Adams (ORCID: https://orcid.org/0000-0003-4280-9070)
- Christine G. Lian (ORCID: https://orcid.org/0000-0003-4626-1612)
- Felix J Klimitz (ORCID: https://orcid.org/0000-0002-1278-0505)
- Naftali Kaminski (ORCID: https://orcid.org/0000-0001-5917-4601)
- William J. Crisler (ORCID: https://orcid.org/0000-0003-1767-9809)
- Leonard Knoedler (ORCID: https://orcid.org/0009-0009-4279-5669)
Institutions
- Brigham and Women's Hospital (US)
- Yale University (US)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1694066
- Citations
- 2
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.01