Construction and evaluation of STZ-induced diabetes and diabetic kidney disease models in C57BL/6J mice
An appropriate dose of STZ in combination with UN and HFD represents an optimal strategy for establishing an STZ-induced DKD model in C57BL/6J mice, effectively recapitulating the clinical and pathological features of human DKD and providing a robust platform for mechanistic research and therapeutic development.
Authors
- Fang Qin (ORCID: https://orcid.org/0000-0001-6779-5416)
- Hao Li (ORCID: https://orcid.org/0000-0002-4633-8256)
- Shanshan Zheng
- Sen Lin (ORCID: https://orcid.org/0000-0002-2253-907X)
- Yipeng Liu (ORCID: https://orcid.org/0000-0003-2084-8781)
- Xinyuan Gao (ORCID: https://orcid.org/0000-0002-8408-4517)
- Jing Wu (ORCID: https://orcid.org/0000-0001-9602-7387)
Institutions
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fendo.2025.1711035
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00