Solute carrier family 1 member 1 in renal interstitial fibrosis: evaluating its influence on glutamate uptake and extracellular ion levels
The downregulation of SLC1A1 during renal interstitial fibrosis is inversely related to the severity of fibrosis and impacts both glutamate uptake and the balance of extracellular ions, indicating its potential as a therapeutic target for enhancing kidney function.
Authors
- Siyuan Luo (ORCID: https://orcid.org/0000-0002-2631-648X)
- Wen Yang (ORCID: https://orcid.org/0000-0003-2314-400X)
- Ting Huang (ORCID: https://orcid.org/0000-0003-4472-5575)
- Xiankui Cheng
- Gang Liu (ORCID: https://orcid.org/0000-0003-2613-7286)
- Shizhen Chen (ORCID: https://orcid.org/0000-0002-4883-5790)
- Cheng Lv
Institutions
- China National Nuclear Corporation (CN)
- Chengdu Medical College (CN)
- Shandong Provincial Hospital (CN)
- Chengdu University (CN)
- Chengdu Second People's Hospital (CN)
- Second Affiliated Hospital of Chengdu University of Traditional Chinese (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fmed.2025.1694428
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology of Sichuan Province
- Chengdu University
- National Health Commission of the People's Republic of China