Case Report: Prenatal diagnosis of a rare complex fetal karyotype 47,U,t(10;13)(p15;q22)mat,+der(13)t(10;13)dmat resulting from 3:1 meiotic segregation of a maternal balanced translocation
This case confirms the pivotal role of integrated G-banding and CNV-seq in diagnosing complex chromosomal rearrangements. For families with a high recurrence risk, PGT is a mandatory intervention to prevent subsequent adverse reproductive outcomes.
Authors
- Guangsheng Deng (ORCID: https://orcid.org/0000-0001-9687-6856)
- W. C. Li (ORCID: https://orcid.org/0009-0000-8037-048X)
- J. J. Pan (ORCID: https://orcid.org/0009-0006-1574-6376)
- Xiaofei Liang (ORCID: https://orcid.org/0000-0002-3279-5894)
- X.C. Li (ORCID: https://orcid.org/0000-0002-5981-2762)
- Yanting Lu (ORCID: https://orcid.org/0000-0002-4075-6983)
- Ning Shen (ORCID: https://orcid.org/0000-0003-4709-3374)
- Deren Li (ORCID: https://orcid.org/0000-0002-7277-6356)
- J. J. Song
- Ying‐Yeh Chen (ORCID: https://orcid.org/0000-0001-5543-5704)
- Yajun Liang (ORCID: https://orcid.org/0000-0001-5236-2095)
- Lingling Li (ORCID: https://orcid.org/0009-0003-8159-9560)
- Yancheng Lai (ORCID: https://orcid.org/0009-0004-8444-7535)
- D. H. Zhang
Institutions
- Yulin Orthopedics Hospital of Chinese and Western Medicine (CN)
Publication Details
- Journal
- Frontiers in Reproductive Health
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/frph.2025.1737392
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00