Dynamic genetic regulation of CD4+ T cells in obstructive sleep apnea: integrating context-specific eQTL, Mendelian randomization, single-cell sequencing, and experimental validation

The immune regulation mediated by CD4⁺ T cells demonstrates significant temporal dynamics and cell type specificity in OSA pathogenesis. Key genes including <i>TUFM</i>, <i>MAST3</i>, <i>FNBP4</i>, <i>SGF29</i>, and <i>SH3YL1</i> participate in the pathological process by regulating mitochondrial function, cell migration, transcriptional regulation, and inflammatory responses. These findings provide a novel theoretical foundation and reveal potential targets for personalized therapeutic strategies and biomarker development in OSA.