A novel fully human anti-ROR1 antibody PBA-0405 optimized for ADCC, induces potent anti-tumor activity against both solid and hematological malignancies
These results underscore the therapeutic potential of 22.0405.aF as a promising immunotherapy for treatment of ROR1-positive B-cell malignancies. Notably, 22.0405.aF has recently completed Phase 0 clinical trials in patients with head and neck carcinomas and soft tissue sarcomas, paving the way for further clinical development.
Authors
- Marek Orłowski (ORCID: https://orcid.org/0000-0003-1282-2282)
- Ying Zhang (ORCID: https://orcid.org/0000-0001-9271-6193)
- Sonia Kołt (ORCID: https://orcid.org/0000-0003-4076-0445)
- Anna Andrzejczak (ORCID: https://orcid.org/0000-0001-6098-7554)
- Piotr Mamczur (ORCID: https://orcid.org/0000-0002-7135-3685)
- Tomasz Klaus (ORCID: https://orcid.org/0000-0003-3233-3646)
- Dariusz Wołowiec (ORCID: https://orcid.org/0000-0003-4081-5397)
- Anna Kostyn
- Sameer Deshmukh
- Ewelina Krzywińska (ORCID: https://orcid.org/0000-0002-4311-2972)
- Jakub Kołodziejski
- Piotr Naporowski (ORCID: https://orcid.org/0000-0002-9412-5511)
- Wondossen Sime (ORCID: https://orcid.org/0000-0001-9518-2457)
- Pieter Spee
- Lidia Karabon (ORCID: https://orcid.org/0000-0001-8172-0971)
- Aleksandra Bielawska‐Pohl (ORCID: https://orcid.org/0000-0002-2757-5571)
- Niina Veitonmäki (ORCID: https://orcid.org/0000-0001-6933-0823)
- Katherine M Soltys
- Ramin Massoumi (ORCID: https://orcid.org/0000-0001-8875-6440)
- Jianming Xu (ORCID: https://orcid.org/0000-0001-9745-7901)
- B Romanowska
- Aleksandra Ziemblicka
- Monika Świtoń
- Sabina Oleksy
- Łukasz Świderski
Institutions
- Wrocław University of Science and Technology (PL)
- University of Wrocław (PL)
- Wroclaw Medical University (PL)
- Pure Biologics (Poland) (PL)
- Grinm Advanced Materials (China) (CN)
- MAX IV Laboratory (SE)
- Ludwik Hirszfeld Institute of Immunology and Experimental Therapy (PL)
- AGH University of Krakow (PL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1711509
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Narodowe Centrum Badań i Rozwoju