Regional abnormalities in the hippocampus and verbal memory impairment in craniofacial dystonia
Our findings reveal a structure-function dissociation in CFD. We propose its verbal memory deficits, despite hippocampal atrophy, may stem from broader network dysfunction or microstructural pathology not seen on conventional MRI. This challenges models assuming a direct link between macrostructural atrophy and cognitive symptoms.
Authors
- Zhicong Yan (ORCID: https://orcid.org/0000-0003-3363-7713)
- Yuhan Luo (ORCID: https://orcid.org/0000-0003-1951-9972)
- Zhengkun Yang
- G Liu (ORCID: https://orcid.org/0009-0002-3765-4297)
- Huiming Liu (ORCID: https://orcid.org/0000-0002-1820-4891)
- Yue Zhang (ORCID: https://orcid.org/0000-0002-1572-7910)
- Weixi Zhang (ORCID: https://orcid.org/0000-0003-4474-3722)
- Zilin Ou
- Xiuye He
- Jinping Xu (ORCID: https://orcid.org/0000-0001-9175-2598)
- Jiana Zhang
- Kangqiang Peng
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Sciences (CN)
- Huizhou Central People's Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fnins.2025.1636362
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province