Integrative proteomics reveals mitochondrial and immune signatures of MLH1 exon 13 deletion in Lynch syndrome–associated colorectal cancer
This study provides the first proteomic evidence linking MLH1-EX13 Del to suppressed mitochondrial metabolism and immune activation. These findings highlight metabolic vulnerability and an inflammatory microenvironment as potential therapeutic targets, offering new insights into Lynch syndrome-associated colorectal cancer.
Authors
- Lin Chen (ORCID: https://orcid.org/0009-0005-1741-0975)
- Yue Cao (ORCID: https://orcid.org/0000-0002-1434-6366)
- Bin Zhang (ORCID: https://orcid.org/0000-0002-2112-2555)
- Chang Chen (ORCID: https://orcid.org/0000-0003-2841-1250)
- Wensheng Li (ORCID: https://orcid.org/0000-0002-1172-3349)
- Guorong Wang (ORCID: https://orcid.org/0000-0001-9163-8322)
- Jingli Chen (ORCID: https://orcid.org/0000-0003-0021-081X)
Institutions
- Shanxi Medical University (CN)
- Shaanxi Provincial People's Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fmolb.2025.1722111
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shaanxi Province