Nrf2/HO-1-sulfiredoxin1 pathway involved in nanobubble hydrogen-dissolved water-mediated protective effects by ultrasound-guided early local injection in a rat model of chronic constriction injury-induced neuropathic pain
Ultrasound-guided early local injection of NHW attenuated sciatic nerve injury, alleviated mechanical allodynia and thermal hyperalgesia and inhibited inflammation and oxidative stress damage via the Nrf2/HO-1-sulfiredoxin1 pathway in a rat model of CCI.
Authors
- Bing Zhang (ORCID: https://orcid.org/0000-0003-4887-8595)
- Hongmin Ma (ORCID: https://orcid.org/0000-0002-7061-8944)
- Zixiao Yin (ORCID: https://orcid.org/0000-0001-7088-8031)
- Junmin Yu (ORCID: https://orcid.org/0000-0001-9501-6440)
- Chao Meng (ORCID: https://orcid.org/0000-0001-6720-1307)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fnmol.2025.1666575
- Primary Topic
- Hydrogen's biological and therapeutic effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00