Effect of progesterone levels on the hCG trigger day and the progesterone-to-basal progesterone ratio on pregnancy outcomes in fresh IVF/ICSI cycles with GnRH antagonist protocol: a retrospective cohort study
For patients with a normal ovarian response undergoing the GnRH-ant protocol, even a slight elevation in P levels on the hCG trigger day affected LBR. Moreover, the impact of the P<sub>hCG</sub>/P<sub>basal</sub> ratio on pregnancy outcomes also warrants attention. A serum P level < 1.06 ng/mL on the hCG trigger day and P<sub>hCG</sub>/P<sub>basal</sub> ratio < 1.2 were associated with a significantly higher LBR. When the P<sub>hCG</sub>/P<sub>basal</sub> ratio ≥ 1.2, the LBR declined regardless of P levels on hCG trigger day. These findings highlight the potential for incorporating P<sub>hCG</sub>/P<sub>basal</sub> ratio considerations into individualized clinical management strategies to optimize pregnancy outcomes.
Authors
- Fang Lian (ORCID: https://orcid.org/0000-0002-6340-3697)
- Shan Xiang (ORCID: https://orcid.org/0000-0002-9129-0933)
- Lu Guan
- Yuan Li (ORCID: https://orcid.org/0000-0002-1683-6801)
- Xin Zhen (ORCID: https://orcid.org/0000-0002-8419-1961)
- Haicui Wu (ORCID: https://orcid.org/0000-0003-3313-3697)
- Qihui Liang
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fendo.2025.1653555
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province