Unveiling novel therapeutic mechanisms of Xinfeng capsule: modulating the ALKBH5–m6A–LINC00968 axis to alleviate oxidative stress-driven NETosis in rheumatoid arthritis
This study unveils a novel ALKBH5-m6A-LINC00968 signaling axis that critically regulates neutrophil hyperactivation and NETosis in RA. XFC attenuates the neutrophil-NET-synovial cell inflammatory cascade by targeting ALKBH5 and promoting m6A methylation of LINC00968, providing an epigenetically regulated therapeutic strategy for RA treatment within a traditional medicine framework.
Authors
- Jian Liu (ORCID: https://orcid.org/0000-0001-7352-6757)
- Yang Li (ORCID: https://orcid.org/0009-0004-3179-3944)
- Yue Sun (ORCID: https://orcid.org/0000-0001-7903-3638)
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
- Hefei Institutes of Physical Science (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1707663
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80