Automated GMP-compatible production of universal CAR Tregs for organ-targeted tolerance induction
The study establishes a scalable, GMP-compatible process for manufacturing pure, stable and functional universal RevCAR Tregs for clinical applications. Furthermore, the RevCAR system offers a promising approach toward an allogenic, off-the-shelf Treg therapy capable of treating diverse immune-mediated diseases with spatial precision.
Authors
- Rebekka Wehner
- Jing-Wun Li
- Katja Peter
- Liliana Rodrigues Loureiro (ORCID: https://orcid.org/0000-0002-7150-6354)
- Anke Fuchs (ORCID: https://orcid.org/0000-0003-3028-0827)
- Ezio E. Bonifacio (ORCID: https://orcid.org/0000-0002-8704-4713)
- Martin Bornhäuser (ORCID: https://orcid.org/0000-0002-5916-3029)
- Claudia Arndt (ORCID: https://orcid.org/0000-0002-1285-5052)
- Michael Bachmann (ORCID: https://orcid.org/0000-0002-8029-5755)
- José Manuel Marín Morales
- Kristina Hölig
- Claudia Peitzsch (ORCID: https://orcid.org/0000-0002-5247-908X)
- Karla Elizabeth González Soto
- Anna Taubenberger (ORCID: https://orcid.org/0000-0002-7916-0394)
- Nicole Berndt (ORCID: https://orcid.org/0000-0001-6921-0848)
- Marc Schmitz (ORCID: https://orcid.org/0000-0003-3417-6736)
- Hinrich Abken (ORCID: https://orcid.org/0000-0002-4302-3240)
- Kavitha M. Lakshmi (ORCID: https://orcid.org/0000-0002-7870-8020)
- Yueyuan Hu
- Anja Feldmann (ORCID: https://orcid.org/0000-0001-5099-2448)
- Samikshya Santosh Nirmala
- Alexandra von Jutrzenka-Trzebiatowski
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- German Red Cross (DE)
- University Hospital Heidelberg (DE)
- Leibniz Association (DE)
- National Center for Tumor Diseases (DE)
- Center for Systems Biology Dresden (DE)
- University Hospital Carl Gustav Carus (DE)
- Deutsche Knochenmarkspenderdatei (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s12967-025-07431-0
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zentrum für Regenerative Therapien Dresden