Hypercalcemia episodes caused by ectopic parathyroid adenoma and subsequent gastrointestinal stromal tumor: A case report and literature review
To our knowledge, this case represents the first reported coexistence of an ectopic parathyroid adenoma and a GIST. 4D-CT and FCH-PET/CT can be used as alternative imaging modalities following <sup>99m</sup>Tc-sestamibi SPECT/CT to locate ectopic parathyroid lesions. The mechanism behind GIST-related hypercalcemia may involve the expression of PTHrP or 1-alpha-hydroxylase in tumor tissues.
Authors
- Yi‐Ching Lin (ORCID: https://orcid.org/0000-0003-4063-0771)
- Wei‐Yih Chiu (ORCID: https://orcid.org/0000-0003-3124-7121)
- Chen‐Yu Wen (ORCID: https://orcid.org/0000-0002-4457-7747)
- Jen‐Chieh Lee (ORCID: https://orcid.org/0000-0001-7739-5934)
Institutions
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fonc.2025.1720028
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Taiwan University Hospital
- National Taiwan University