Inulin and Lycium barbarum polysaccharides mitigate the diabetic inflammatory response by modulating bile acid metabolism to enhance regulatory T cell (Treg) activation in a rat model of diabetes
INU and LBP modulate bile acids derived from intestinal flora to improve the chronic inflammatory status of diabetic rats. Specifically, both exert their effectiveness by regulating gut microbial bile acid metabolites through the FXR-FGF15-FGFR4 axis to activate Treg cells. These findings provide an experimental basis for further exploration of the mechanism underlying the effects of this combination in diabetic animal models, which may contribute to clinical therapeutic practice for the control of the disease.
Authors
- Hongxia Ma (ORCID: https://orcid.org/0000-0002-4477-613X)
- Hongyan Luo (ORCID: https://orcid.org/0000-0003-3845-2400)
- Qian Zhao (ORCID: https://orcid.org/0000-0002-2943-0229)
- Peiling Li (ORCID: https://orcid.org/0000-0002-1894-235X)
- Shilu Cao (ORCID: https://orcid.org/0000-0002-5222-7296)
- Yan Yang (ORCID: https://orcid.org/0000-0002-1860-2857)
- Haixia Lü (ORCID: https://orcid.org/0000-0002-9787-1771)
- Yali Zheng (ORCID: https://orcid.org/0000-0002-0359-2799)
- Hao Wang (ORCID: https://orcid.org/0000-0002-5776-8681)
- Yanfang Zhang (ORCID: https://orcid.org/0000-0001-7614-0067)
Institutions
- Ningxia Hui Autonomous Region Peoples Hospital (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fendo.2025.1705635
- Citations
- 1
- Primary Topic
- Microbial Metabolites in Food Biotechnology
- Type
- article
- Field-Weighted Citation Impact
- 1.12