Associations of cardiorespiratory fitness indicators with brain volumes and cognitive function in patients with coronary artery disease: findings from the Heart–Brain trial
In CAD patients, both maximal and submaximal CRF-indicators were associated with larger brain volumes, with stronger region-specific association with HV, and younger physiological appearance of the brain, while associations with cognitive functions were fewer and weaker. Our findings support CRF as a biomarker of structural brain health in CAD patients.
Authors
- Anna Carlén (ORCID: https://orcid.org/0000-0001-9196-7820)
- Kirk I. Erickson (ORCID: https://orcid.org/0000-0001-8736-981X)
- Ricardo Rivera-López (ORCID: https://orcid.org/0000-0002-0787-9383)
- Rosa María Alonso Cuenca (ORCID: https://orcid.org/0009-0001-6121-5457)
- Marcos Olvera‐Rojas (ORCID: https://orcid.org/0000-0001-7922-1647)
- Darío Bellón (ORCID: https://orcid.org/0009-0008-7289-8776)
- Patricio Solis‐Urra (ORCID: https://orcid.org/0000-0002-2493-9528)
- Javier Sanchez‐Martinez (ORCID: https://orcid.org/0000-0002-9451-8454)
- Irene Esteban‐Cornejo (ORCID: https://orcid.org/0000-0002-0027-1770)
- Francisco B. Ortega (ORCID: https://orcid.org/0000-0003-2001-1121)
- Isabel Martín‐Fuentes (ORCID: https://orcid.org/0000-0003-4268-1935)
- Ángel Toval (ORCID: https://orcid.org/0000-0003-4798-1216)
- Rafael Peñafiel-Burkhardt (ORCID: https://orcid.org/0000-0001-5354-8422)
- Alessandro Sclafani (ORCID: https://orcid.org/0009-0008-6573-6867)
- Beatriz Fernandez‐Gamez (ORCID: https://orcid.org/0000-0002-8987-9925)
- Lucía Sánchez‐Aranda (ORCID: https://orcid.org/0009-0001-0234-8751)
- Emilio J. Barranco‐Moreno (ORCID: https://orcid.org/0009-0006-1168-1931)
- José Pablo Martínez Barbero (ORCID: https://orcid.org/0000-0003-4217-0633)
- Alberto González‐García (ORCID: https://orcid.org/0000-0001-7314-1435)
- Javier Fernández‐Ortega (ORCID: https://orcid.org/0000-0002-9236-9504)
- Andrea Coca‐Pulido (ORCID: https://orcid.org/0009-0008-1249-6353)
Institutions
- Linköping University (SE)
- Universidad de Granada (ES)
- AdventHealth Orlando (US)
- Instituto de Salud Carlos III (ES)
- Viña del Mar University (CL)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Hospital Universitario Virgen de las Nieves (ES)
- Industrial Development Center (Sweden) (SE)
- Translational Research Institute for Metabolism and Diabetes (US)
- University of Jyväskylä (FI)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1093/eurjpc/zwaf765
- Citations
- 2
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 2.23