Increased first-trimester CA125 levels associated with the development of preeclampsia
First-trimester serum CA125 serves as a robust and independent predictor of preeclampsia. Its integration with established clinical risk factors significantly improves predictive accuracy, facilitating early identification of of PE. The specific association of CA125 with accelerated blood pressure trajectories through gestation suggests its role as an early sentinel of aberrant placental-vascular pathophysiology. These findings position CA125 as a promising and practical biomarker for enhancing early risk stratification.
Authors
- Aiqi Yin (ORCID: https://orcid.org/0000-0001-8282-8052)
- Cuiping Zeng (ORCID: https://orcid.org/0000-0002-0689-7491)
- Linlin Wu (ORCID: https://orcid.org/0000-0003-1575-7180)
- Xiaonian Guan
- Jianmin Niu (ORCID: https://orcid.org/0000-0002-1182-5994)
- Huafan Zhang (ORCID: https://orcid.org/0000-0002-8172-2632)
- Kan Liu (ORCID: https://orcid.org/0009-0009-9974-6518)
- Yixuan Chen (ORCID: https://orcid.org/0000-0002-4879-7165)
- Pingping Huang (ORCID: https://orcid.org/0000-0003-0191-2610)
- Xiaoxia Wu (ORCID: https://orcid.org/0000-0002-8549-6361)
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Henan Provincial People's Hospital (CN)
- Guangdong Province Women and Children Hospital (CN)
- Zhengzhou People's Hospital (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s12967-025-07565-1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00