Prostate cancer risk-associated single-nucleotide polymorphisms impact the conformational dynamics of prostate-specific antigen
These data show that KLK3 SNPs disrupt dynamic communication of the key loops required for proteolytic activity of PSA, which may explain the association of these SNPs with prostate cancer risk and/or progression.
Authors
- Hannu Koistinen (ORCID: https://orcid.org/0000-0003-0926-3109)
- Judith A. Clements (ORCID: https://orcid.org/0000-0001-6026-1964)
- Ashley M. Buckle (ORCID: https://orcid.org/0000-0003-2943-9044)
- Maurício G. S. Costa (ORCID: https://orcid.org/0000-0001-5443-286X)
- Emily Wilson (ORCID: https://orcid.org/0000-0002-8658-4072)
- Blake T. Riley (ORCID: https://orcid.org/0000-0003-2176-0503)
- Jyotsna Batra (ORCID: https://orcid.org/0000-0003-4646-6247)
- Itamar Kass (ORCID: https://orcid.org/0000-0002-5368-937X)
- Brooke K. Hayes
- David E. Hoke (ORCID: https://orcid.org/0000-0003-4975-4391)
- Emilia M. Marijanovic
- Srilakshmi Srinivasan (ORCID: https://orcid.org/0000-0002-3900-1727)
Institutions
- Bond University (AU)
- Translational Research Institute (AU)
- University of Helsinki (FI)
- Queensland University of Technology (AU)
- Helsinki University Hospital (FI)
- Australian Regenerative Medicine Institute (AU)
- San Diego Biomedical Research Institute (US)
- Fundação Oswaldo Cruz (BR)
- Monash University (AU)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s12915-025-02458-7
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00