DNA methylation-based clocks, tobacco smoking, and lung cancer risk
Methylation-based biological clocks capture epigenetic marks left by exposure to tobacco smoke, and some clocks may inform lung cancer risk assessment by complementing or replacing traditional prediction models.
Authors
- James McKay
- Torkjel Manning Sandanger (ORCID: https://orcid.org/0000-0002-4062-872X)
- Pierre‐Antoine Dugué (ORCID: https://orcid.org/0000-0003-2736-3023)
- Mikael Johansson (ORCID: https://orcid.org/0000-0002-2237-2580)
- Mattias Johansson (ORCID: https://orcid.org/0000-0002-3116-5081)
- Roger Laughlin Milne (ORCID: https://orcid.org/0000-0001-5764-7268)
- Matthew Suderman (ORCID: https://orcid.org/0000-0002-2715-9930)
- Caroline L. Relton (ORCID: https://orcid.org/0000-0003-2052-4840)
- Therese Haugdahl Nøst (ORCID: https://orcid.org/0000-0001-6805-3094)
- Ricardo Cortez Cardoso Penha (ORCID: https://orcid.org/0000-0002-2847-1993)
- Ryan Langdon (ORCID: https://orcid.org/0000-0003-3543-6480)
- Justina Ucheojor Onwuka (ORCID: https://orcid.org/0000-0002-4236-1758)
- Paolo Vineis (ORCID: https://orcid.org/0000-0001-8935-4566)
Institutions
- University of London (GB)
- The University of Melbourne (AU)
- Cancer Council Victoria (AU)
- University of Bristol (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Monash Health (AU)
- Centre international de recherche sur le cancer (FR)
- MRC Centre for Environment and Health
- Imperial College London (GB)
- Monash University (AU)
- UiT The Arctic University of Norway (NO)
- Umeå University (SE)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s12916-025-04542-9
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00