Proteomics Analysis of Plasma for Risk of Sepsis: Findings from the Atherosclerosis Risk in Communities Study
In this analysis, levels of acute inflammatory proteins measured during routine visits were associated with the subsequent incidence of sepsis. An increased risk of sepsis associated with the inhibition of anti-inflammatory pathways, such as LXR/RXR warrants further mechanistic investigation.
Authors
- Xiao Hu (ORCID: https://orcid.org/0000-0002-1515-1042)
- Morgan E. Grams (ORCID: https://orcid.org/0000-0002-4430-6023)
- Junichi Ishigami (ORCID: https://orcid.org/0000-0002-6396-3723)
- Jingsha Chen
- Pascal Schlosser (ORCID: https://orcid.org/0000-0002-8460-0462)
- Josef Coresh (ORCID: https://orcid.org/0000-0002-4598-0669)
- Christie Mitchell Ballantyne (ORCID: https://orcid.org/0000-0002-6432-1730)
- Thomas R. Austin
- James S. Floyd (ORCID: https://orcid.org/0000-0002-0365-9041)
- David W. Dowdy (ORCID: https://orcid.org/0000-0003-0481-7475)
- Kunihiro Matsushita (ORCID: https://orcid.org/0000-0002-7179-718X)
- Bruce M. Psaty
Institutions
- Johns Hopkins University (US)
- University of Freiburg (DE)
- Baylor College of Medicine (US)
- University of Washington (US)
- University Medical Center Freiburg (DE)
- NYU Langone Health (US)
- Department of Health (TW)
Publication Details
- Journal
- The Journal of Applied Laboratory Medicine
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1093/jalm/jfaf179
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute