Weekly Oral Prophylaxis With MK-8527 Protects Rhesus Macaques From Intrarectal Challenge With Simian–Human Immunodeficiency Virus
Prophylaxis with MK-8527 completely protected macaques from SHIV infection, supporting its further clinical development for prevention of HIV-1 acquisition.
Authors
- Winnie Ngo
- Tracy L. Diamond (ORCID: https://orcid.org/0000-0002-4672-8641)
- Melissa A. Boddicker (ORCID: https://orcid.org/0000-0002-5944-1738)
- Ernest Asante‐Appiah
- Jane Fontenot (ORCID: https://orcid.org/0000-0002-1846-7915)
- François Villinger (ORCID: https://orcid.org/0000-0002-7790-2008)
- J. Maxwell
- Yash Kapoor (ORCID: https://orcid.org/0000-0002-2281-4115)
- Bang-Lin Wan (ORCID: https://orcid.org/0000-0003-4563-2629)
- Henry S. Lange (ORCID: https://orcid.org/0000-0001-6271-2597)
- Fangbiao Li (ORCID: https://orcid.org/0000-0003-1668-143X)
- Kerry L. Fillgrove
- Shubing Wang
- Jay A. Grobler
- Kelly A Soileau
Institutions
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- University of Louisiana at Lafayette (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1093/infdis/jiaf610
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00