Human papillomavirus-related oropharyngeal squamous cell carcinoma exhibits enhanced radiosensitivity despite limited activation of cytosolic DNA sensing pathways and innate immune responses
The key finding was that the involvement of cytosolic DNA sensing pathways and innate immune system do not increase radiosensitivity of HPV16-related OPSCC. In PSCC models, DNA sensor and cytokine expression varied depending on IR dose and fractionation.
Authors
- Kristina Levpuscek
- Primož Strojan (ORCID: https://orcid.org/0000-0002-0445-112X)
- Tanja Jesenko (ORCID: https://orcid.org/0000-0001-5883-1673)
- Simona Kranjc (ORCID: https://orcid.org/0000-0003-0538-7841)
- Tilen Komel (ORCID: https://orcid.org/0000-0002-4989-9059)
- Maja Čemažar (ORCID: https://orcid.org/0000-0002-1418-1928)
- Gregor Serša (ORCID: https://orcid.org/0000-0002-7641-5670)
Institutions
- University of Primorska (SI)
- University of Ljubljana (SI)
- Institute of Oncology Ljubljana (SI)
Publication Details
- Journal
- Radiology and Oncology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2478/raon-2025-0057
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00